Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta

Figure 8

Schematic representation of the underlying mechanisms of the GPS-promoted vasodilatation effects in aortic rings. (1) GPS inhibited extracellular Ca²⁺ influx in the cell membrane and intracellular Ca²⁺ release through IP₃R- and RYR-mediated Ca²⁺ channels in the sarcoplasmic reticulum by inhibition of VDCC and ROCC. (2) GPS may activate K⁺ channels. (3) GPS inhibited PI3K/Akt/Rho-kinase and L-type Ca²⁺ channel pathways.