Use of Network Pharmacology to Investigate the Mechanism of the Compound Xuanju Capsule in the Treatment of Rheumatoid Arthritis

Table 3

The information of top 20 common targets.

Gene	Protein	UniProt ID	Degree	Betweenness centrality	Closeness centrality	Neighborhood connectivity
IL6	Interleukin-6	P05231	93	667.9930402	0.833333333	89.12839505
GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	P04406	91	719.0841193	0.815602837	85.92631575
VEGFA	Vascular endothelial growth factor A	P15692	89	413.5753955	0.793103448	84.52425102
TNF	Tumor necrosis factor	P01375	89	335.4934403	0.798611111	84.68661002
AKT1	RAC-alpha serine/threonine-protein kinase	P31749	87	524.2608782	0.798611111	80.85548315
MAPK3	Mitogen-activated protein kinase 3	P27361	84	410.4623204	0.777027027	76.40073952
TP53	Cellular tumor antigen p53	P04637	81	307.2138965	0.746753247	73.70696197
CXCL8	Interleukin-8	P10145	78	218.2893964	0.732484076	70.86636431
PTGS2	Prostaglandin G/H synthase 2	P35354	78	206.0168462	0.737179487	69.98848441
EGF	Proepidermal growth factor	P01133	76	261.8569934	0.737179487	65.03746714
MMP9	Matrix metalloproteinase-9	P14780	76	433.8806129	0.71875	68.81580781
CCL2	C-C motif chemokine 2	P13500	75	157.4214188	0.72327044	67.00969048
IL10	Interleukin-10	P22301	74	145.584267	0.71875	65.80203946
IL1β	Interleukin-1 beta	P01584	74	158.014336	0.71875	65.60821648
MAPK8	Mitogen-activated protein kinase 8	P45983	73	129.355471	0.709876543	65.62343779
JUN	Transcription factor AP-1	P05412	73	122.1960842	0.709876543	66.15527831
CASP3	Caspase-3	P42574	72	107.386397	0.701219512	64.73650484
MAPK1	Mitogen-activated protein kinase 1	P28482	71	166.1161984	0.705521472	61.56264833
MYC	Myc proto-oncogene protein	P01106	64	147.9851483	0.67251462	54.86995265
MMP2	72 kDa type IV collagenase	P08253	62	74.82792554	0.66091954	52.92741783