Minimal Intervention in Dentistry: A Literature Review on Biodentine as a Bioactive Pulp Capping Material

Figure 2

Reparative dentine formation involves a series of events in which a severe stimulus (e.g., pulp exposure) causes death of the primary odontoblast, which are then replaced following differentiation of progenitor cells into odontoblast-like cells under the regulation of bioactive molecules released from the dentine matrix. The bioactive molecules are released by caries, irrigants, and dental materials (e.g., MTA, Biodentine) (reprinted from International Endodontic Journal, 52(7), H. F. Duncan, P. L. Tomson, S. Simon, et al., Management of deep caries and the exposed pulp, 949-973., 2019, with permission from John Wiley and Sons).