Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro

<div>CED treatment induced G1 phase arrest in A549 cells after 48 h. (a) Cell cycle distribution in A549 cells pretreated with the indicated concentration of CED at the time point of 48 h. DNA content of cells stained with PI was detected using flow cytometry. (b) The percentage of the cell population in each phase was quantitatively analyzed after exposure to the indicated CED for 48 h. (c) After CED treatment, G1 phase relative proteins CDK2, cyclin E, CDK4, and cyclin D1 were detected by western blot analysis. (d) Quantitative analysis of CDK2, cyclin E, CDK4, and cyclin D1 proteins was represented by column graphs. 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BioMed Research International

fig4

Figure 4

Figure 4: Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro 