Research Article
Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer
Figure 1
The expression level analysis. (a) Heat map of the correlation coefficient from all samples. The color of the panel is the correlation coefficient of the two samples. The blue represents the two samples with a high correlation coefficient, and the white represents the minimal similarity of the two samples. (b) PCA of strongly expressed tRFs and tiRNAs showed a complete separation of HGSOC and normal controls. PCA: principal component analysis. (c) Venn diagram founded on the number of commonly expressed and specifically expressed tRFs and tiRNAs. This diagram is the number of tRFs and tiRNAs which were expressed in both groups and indicated the number of specifically expressed tRFs and tiRNAs. (d) A total of 312 tRNA derivatives were identified by tRFs and tiRNA-seq in this study, and 268 of them were identified as novel tRNA derivatives that had not been annotated in the tRFdb database.
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