Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer

Figure 4

Identification of tRFs and tiRNAs related to HGSOC. (a) Scatter plot of differentially expressed tRFs and tiRNAs: dark gray points above the top line show upregulation, and light gray points below the bottom line represent downregulation; black dots indicate genes without differential expression. (b) Volcano plot of differentially expressed tRFs and tiRNAs in HGSOC. The vertical lines correspond to twofold increased and decreased expression, and the horizontal light gray line represents . The dark gray and light gray points represent tRFs and tiRNAs that were differentially upregulated and downregulated with statistical significance. (c) Heat maps of differentially expressed tRFs and tiRNAs in normal and HGSOC. (d) Relative expression levels of six most differentially expressed tRNA derivatives in HGSOC and paired normal. (e) Detailed annotation of tRF and tiRNA-mRNA interaction between tRF-Leu-AAG and its target mRNAs by computational predictions at the sequence level.

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