Network Pharmacological Study of Achyranthis bidentatae Radix Effect on Bone Trauma

Figure 2

Action view of the PPIN network of ABR targets. Action type is denoted by colored edges: activation, inhibition, binding, catalysis, phenotype, posttranslational modification, reaction, and transcriptional regulation. Action effects are shown by the following: positive, negative and unspecified. Note: ESR1: estrogen receptor 1; MMP2: matrix metallopeptidase 2; CCL2: chemokine (C-C motif) ligand 2; MAPK14: mitogen-activated protein kinase 14; ZFP36: zinc finger protein 36, C3H type, homolog (mouse); CMA1: chymase 1, mast cell; IL6: interleukin 6 (interferon, beta 2); MMP3: matrix metallopeptidase 3 (stromelysin 1, progelatinase); PLA2G1B: phospholipase A2, group IB (pancreas); MMP1: matrix metallopeptidase 1 (interstitial collagenase); CYP1A2: cytochrome P450, family 1, subfamily A, polypeptide 2; CTSB: cathepsin B; SRC: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); PTGS2: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); JUN: jun protooncogene; ALOX5: arachidonate 5-lipoxygenase; FOS: FBJ murine osteosarcoma viral oncogene homolog; MAPK8: mitogen-activated protein kinase 8; MAPK9: mitogen-activated protein kinase 9; BCAR1: breast cancer antiestrogen resistance 1; TIMP2: TIMP metallopeptidase inhibitor 2; IL6R: interleukin 6 receptor; ATF2: activating transcription factor 2; PTPN1: protein tyrosine phosphatase, nonreceptor type 1; NCOA3: nuclear receptor coactivator 3; MAPK10: mitogen-activated protein kinase 10.