Network Pharmacological Study of Achyranthis bidentatae Radix Effect on Bone Trauma

Table 3

Functional enrichments in the PPIN.

Biological process (GO)
Pathway ID	Pathway description	Count in gene set	False discovery rate
GO:0071310	Cellular response to organic substance	19	1.18-11
GO:0031349	Positive regulation of defense response	12	3-11
GO:0031347	Regulation of defense response	14	4.31-11
GO:0050778	Positive regulation of immune response	13	4.31-11
GO:0010243	Response to organonitrogen compound	14	8.28-11
Molecular function (GO)
Pathway ID	Pathway description	Count in gene set	False discovery rate
GO:0004705	JUN kinase activity	3	1.87-06
GO:0004707	MAP kinase activity	4	1.87-06
GO:0005515	Protein binding	20	1.87-06
GO:0019899	Enzyme binding	12	9.59-06
GO:0008134	Transcription factor binding	7	0.000272
Cellular component (GO)
Pathway ID	Pathway description	Count in gene set	False discovery rate
GO:0005615	Extracellular space	10	0.00162
GO:0005896	Interleukin-6 receptor complex	2	0.00381
GO:0005829	Cytosol	12	0.0337
GO:0005901	Caveola	3	0.0337
GO:0044421	Extracellular region part	13	0.0337
KEGG pathways
Pathway ID	Pathway description	Count in gene set	False discovery rate
04668	TNF signaling pathway	10	1.28-14
05142	Chagas disease (American trypanosomiasis)	7	3.52-09
04917	Prolactin signaling pathway	6	1.85-08
05133	Pertussis	6	1.85-08
05161	Hepatitis B	7	1.95-08