Network Pharmacological Study of Achyranthis bidentatae Radix Effect on Bone Trauma

Table 4

GO terms and associated genes obtained through ClueGO.

GO ID	GO term	Term p value (¤)	Group p value (¤)	Associated genes found
GO:0038128	ERBB2 signaling pathway	8.32-05 (8.32-04)	8.32-05 (1.66-04)	[KRAS, SHC1, SRC]
GO:0051353	Positive regulation of oxidoreductase activity	1.73-04 (1.21-03)	1.73-04 (1.73-04)	[CCS, ESR1, KRAS]
GO:0007254	JNK cascade	3.78-10 (1.32-08)	4.05-14 (2.03-13)	[MAP2K4, MAP2K7, MAP3K11, MAPK10, MAPK8, MAPK9, PTPN1, RB1CC1, TAOK3]
GO:0044236	Multicellular organism metabolic process	4.85-07 (1.31-05)	3.90-08 (1.17-07)	[CCL2, CTSB, MMP1, MMP2, MMP3, PLA2G1B]
GO:0031295	T cell costimulation	1.50-06 (3.45-05)	1.77-08 (7.08-08)	[CSK, DPP4, FYN, LCK, SRC]
GO:0043406	Positive regulation of MAP kinase activity	1.58-12 (5.68-11)	2.05-18 (1.23-17)	[CSK, KRAS, MAP2K4, MAP2K7, MAP3K11, MAPK10, PLA2G1B, PTPN1, SHC1, SRC, TAOK3]

Corrected with Bonferroni step down.