B7-H4 Expression in Precancerous Lesions of the Uterine Cervix

Table 1

Patient characteristics as well as factors associated with the absence of lesions in excised conization tissues in patients who had undergone uterine cervical biopsies ().

Characteristics	Group		Lesion in excision specimens, (%)		value
			Present	Absent
Age (years)	≤35	277	245 (88.4)	32 (11.6)	0.413
	>35	530	458 (86.4)	72 (13.6)
Menopause	Yes	65	45 (69.2)	20 (30.8)	<0.001
	No	742	658 (88.7)	84 (11.3)
Referral cytology	NILM	43	36 (83.7)	7 (16.3)	0.038
	ASCUS/LSIL	377	323 (85.7)	54 (14.3)
	ASC-H/HSIL	210	196 (93.3)	14 (6.6)
	Cancer	7	6 (85.7)	1 (14.3)
Referral HPV DNA ()	Positive	577	501 (86.8)	76 (13.2)	0.01
	Negative	54	40 (74.0)	14 (26.0)
Punch biopsy	CIN1	43	34 (79.0)	9 (20.9)	<0.01
	CIN2	259	206 (79.5)	53 (20.5)
	CIN3	504	462 (91.7)	42 (8.3)
Number of biopsies	<4	134	119 (88.8)	15 (11.2)	0.760
	4	612	532 (86.9)	80 (13.1)
	>4	61	52 (85.2)	9 (14.8)
Colposcopy examination ()	Adequacy	327	292 (89.3)	35 (10.7)	0.039
	Inadequacy	84	68 (81.0)	16 (19.0)
Glandular involvement ()	Free	418	348 (83.3)	70 (16.7)	<0.01
	Involved	379	347 (91.6)	32 (8.4)
Depth of conization	≤18 mm	333	279 (83.8)	54 (16.2)	0.022
	>18 mm	468	418 (89.3)	50 (10.7)
Interval between biopsy and excision (months)	<1	428	370 (86.4)	58 (13.6)	0.918
	1–2	153	134 (87.6)	19 (12.4)
	2–3	29	24 (82.8)	5 (17.2)
	>3	30	26 (86.7)	4 (13.3)
Conization methods	CKC	563	502 (89.2)	61 (10.8)	0.008
	LEEP	243	200 (82.3)	43 (17.7)

CKC: cold knife conization; LEEP: loop electrosurgical excision procedure; CIN: cervical intraepithelial neoplasia; HPV: human papilloma virus; TCT: thin-prep test; ASCUS: atypical squamous cells; LSIL: low-grade squamous intraepithelial lesion; ASC-H: atypical squamous cells (cannot exclude high-grade squamous intraepithelial lesions); HSIL: high-grade squamous intraepithelial lesion; NILM: negative for intraepithelial lesion or malignancy.