Mass Spectrometry and Computer Simulation Predict the Interactions of AGPS and HNRNPK in Glioma

Figure 5

Prediction of interaction mode between AGPS and HNRNPK. (a) HNPNRK protein and AGPS protein docking diagram; (b) HNPNRK protein and AGPS protein binding interface key amino acid residue interaction diagram, yellow represents HNPNRK protein, blue represents AGPS protein, green dotted line represents hydrogen bond, and brown represents pi interaction; (c, d) hydrophobic distribution at the binding interface of the HNRPK-AGPS complex; (c) represents AGPS protein and (d) represents HNRNPK protein, blue is hydrophilic residue, and brown is hydrophobic residue; (e) the electrostatic potential distribution map of the front structure of the HNRNPK-AGPS complex; (f) the electrostatic potential distribution map of the back structure of the HNRNPK-AGPS complex; (g) the electrostatic potential distribution map at the binding interface of the HNRNPK-AGPS complex; blue is the positive potential area, red is the negative potential area; yellow represents HNRPK; and blue represents AGPS.