Serum TNF-α Level as a Possible Predictor of Inhibitor Levels in Severe Hemophilia A
Table 2
Correlation between serum TNF-α level and FVIII inhibitor.
TNF-α (pg/mL)
FVIII inhibitor (BU/mL)
Low titer
High titer
Bleeding episodes
Age of the start of therapy
FVIII frequency replacement therapy
Bleeding episodes
Age of the start of therapy
FVIII frequency replacement therapy
a
b
c
d
e
f
a
b
c
d
e
f
Median
10.5
11.4
9.3
11.3
11.2
11.3
10.7
12.8
14.1
11.5
10.0
13.1
Range
6.5-15.4
8.0-302.5
8.6-15.9
8.0-302.5
6.5-15.9
8.0-302.5
8.4-14.4
7.7-97.4
10.0-18.8
7.7-97.4
8.4-4.4
7.7-97.4
value
0.218
0.423
0.441
0.171
0.094
0.028
a = bleeding /month; b = bleeding /month; c = age of the start of month old; d = age start month old; e = FVIII frequency replacement /month; f = FVIII frequency replacement .
