Lack of Association between Common Polymorphisms in Selenoprotein P Gene and Susceptibility to Colorectal Cancer, Breast Cancer, and Prostate Cancer: A Meta-Analysis

Table 2

Characteristics of case-control studies on SEPP1 polymorphisms and cancer risk included in the meta-analysis.

Variants	Author	Year	Tumor type	Ethnicity	Genotyping method	Source of controls	Case			Control
							GG	GA	AA	GG	GA	AA	(HWE)
rs7579	Méplan et al.	2013	BC	European	TaqMan	PB	455	396	86	436	420	101	0.992
	Steinbrecher et al.	2010	PCa	European	MALDI-TOF	PB	116	105	27	250	209	33	0.224
	Méplan et al.	2010	CRC	European	KASPar	HB	260	369	61	269	323	37	≤0.001
	Sutherland et al.	2010	CRC	Asian	PCR-RFLP	HB	190	121	32	363	239	67	0.004
	Amini et al.	2019	CRC	Asian	PCR-HRM	PB	24	22	14	40	23	11	0.022
rs3877899	Steinbrecher et al.	2010	PCa	European	MALDI-TOF	PB	152	86	10	271	194	27	0.309
	Cooper et al.	2008	PCa	European	TaqMan	PB	1522	949	172	878	595	97	0.775
	Geybels et al.	2013	PCa	European	MALDI-TOF	PB	758	441	53	739	426	67	0.585
	Karunasinghe et al.	2012	PCa	European	TaqMan	PB	153	88	18	255	162	19	0.286
	Méplan et al.	2010	CRC	European	KASPar	HB	427	258	47	409	204	44	0.009
	Sutherland et al.	2010	CRC	Asian	PCR-RFLP	HB	797	5	0	710	1	0	0.985
	Méplan et al.	2013	BC	European	TaqMan	PB	586	321	30	594	317	48	0.499
	Jablonska et al.	2015	BC	European	TaqMan	PB	81	44	9	122	55	6	0.948
	Mohammaddoust et al.	2017	BC	Asian	PCR-RFLP	PB	80	37	33	151	33	16	≤0.001

BC: breast cancer; PCa: prostate cancer; CRC: colorectal cancer; PB: population-based; HB: hospital-based; MALDI-TOF: matrix-assisted laser desorption/ionizing time-of-flight mass spectrometry; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; PCR-HRM: polymerase chain reaction high-resolution melting method; KASPar: KBiosciences’ Competitive Allele-Specific PCR; TaqMan: TaqMan fluorescent probe method.