Lack of Association between Common Polymorphisms in Selenoprotein P Gene and Susceptibility to Colorectal Cancer, Breast Cancer, and Prostate Cancer: A Meta-Analysis
Table 3
Subgroup analyses of the SEPP1 polymorphisms and cancer risk.
Variants
Comparison
Subgroup
value
Regression model
Random
Fixed
rs3877899
A vs. G
Overall
9
≤0.001
0.243
0.104
1.099 (0.938-1.287)
1.008 (0.948-1.071)
A vs. G
PCa
4
0.514
0.206
0.954 (0.885-1.027)
0.953 (0.885-1.027)
A vs. G
BC
3
≤0.001
0.240
1.480 (0.770-2.844)
1.134 (0.992-1.295)
A vs. G
PB
7
≤0.001
0.335
1.093 (0.912-1.310)
0.993 (0.931-1.059)
A vs. G
Y
7
0.293
0.231
0.962 (0.888-1.042)
0.961 (0.899-1.026)
A vs. G
European
7
0.269
0.434
0.979 (0.910-1.055)
0.976 (0.917-1.038)
AA vs. GG
Overall
8
≤0.001
0.498
0.337
1.129 (0.794-1.605)
1.021 (0.871-1.196)
AA vs. GG
PCa
4
0.206
0.604
0.946 (0.718-1.246)
0.949 (0.780-1.155)
AA vs. GG
BC
3
≤0.001
0.405
1.726 (0.478-6.237)
1.269 (0.902-1.784)
AA vs. GG
PB
7
≤0.001
0.483
1.162 (0.765-1.765)
1.020 (0.861-1.210)
AA vs. GG
Y
6
0.081
0.599
0.925 (0.693-1.236)
0.917 (0.767-1.095)
AA vs. GG
European
7
0.124
0.397
0.936 (0.738-1.187)
0.931 (0.790-1.098)
AG vs. GG
Overall
9
0.036
0.603
0.109
1.035 (0.909-1.179)
1.003 (0.928-1.084)
AG vs. GG
PCa
4
0.585
0.156
0.934 (0.850-1.027)
0.934 (0.850-1.026)
AG vs. GG
BC
3
0.046
0.203
1.300 (0.868-1.947)
1.123 (0.948-1.331)
AG vs. GG
PB
7
0.072
0.975
0.998 (0.875-1.138)
0.976 (0.898-1.060)
AG vs. GG
Y
7
0.478
0.351
0.960 (0.883-1.044)
0.961 (0.884-1.045)
AG vs. GG
European
7
0.308
0.703
0.989 (0.904-1.082)
0.985 (0.911-1.065)
AG+AA vs. GG
Overall
9
0.001
0.356
0.098
1.079 (0.919-1.267)
1.008 (0.936-1.085)
AG+AA vs. GG
PCa
4
0.623
0.152
0.936 (0.855-1.025)
0.936 (0.855-1.025)
AG+AA vs. GG
BC
3
≤0.001
0.210
1.474 (0.804-2.704)
1.150 (0.980-1.350)
AG+AA vs. GG
PB
7
0.001
0.551
1.056 (0.884-1.261)
0.984 (0.909-1.064)
AG+AA vs. GG
Y
7
0.452
0.266
0.955 (0.881-1.034)
0.956 (0.882-1.035)
AG+AA vs. GG
European
7
0.317
0.553
0.981 (0.901-1.068)
0.978 (0.907-1.054)
AA vs. AG+GG
Overall
8
0.001
0.555
0.371
1.103 (0.797-1.526)
1.017 (0.871-1.189)
AA vs. AG+GG
PCa
4
0.176
0.811
0.974 (0.733-1.295)
0.977 (0.806-1.184)
AA vs. AG+GG
BC
3
≤0.001
0.445
1.580 (0.489-5.108)
1.199 (0.856-1.681)
AA vs. AG+GG
PB
7
0.001
0.497
1.143 (0.777-1.681)
1.027 (0.869-1.215)
AA vs. AG+GG
Y
6
0.067
0.699
0.944 (0.704-1.265)
0.936 (0.786-1.115)
AA vs. AG+GG
European
7
0.113
0.444
0.940 (0.741-1.192)
0.939 (0.799-1.103)
rs7579
A vs. G
Overall
5
0.015
0.309
0.233
1.090 (0.923-1.286)
1.044 (0.958-1.137)
A vs. G
CRC
3
0.079
0.236
1.148 (0.914-1.443)
1.125 (0.995-1.273)
A vs. G
European
3
0.013
0.449
1.084 (0.880-1.335)
1.047 (0.952-1.152)
A vs. G
PB
3
0.015
0.405
1.137 (0.840-1.539)
1.01 (0.892-1.123)
A vs. G
N
3
0.079
0.236
1.148 (0.914-1.443)
1.125 (0.995-1.273)
AA vs. GG
Overall
5
0.014
0.230
0.157
1.267 (0.861-1.866)
1.128 (0.923-1.379)
AA vs. GG
CRC
3
0.091
0.204
1.387 (0.837-2.296)
1.329 (0.989-1.786)
AA vs. GG
European
3
0.007
0.337
1.310 (0.755-2.274)
1.147 (0.910-1.445)
AA vs. GG
PB
3
0.019
0.383
1.334 (0.698-2.548)
1.043 (0.802-1.356)
AA vs. GG
N
3
0.091
0.204
1.387 (0.837-2.296)
1.329 (0.989-1.786)
AG vs. GG
Overall
5
0.315
0.715
0.264
1.029 (0.900-1.177)
1.022 (0.908-1.151)
AG vs. GG
CRC
3
0.357
0.223
1.112 (0.932-1.327)
1.112 (0.937-1.321)
AG vs. GG
European
3
0.190
0.753
1.034 (0.866-1.234)
1.022 (0.895-1.166)
AG vs. GG
PB
3
0.276
0.693
0.994 (0.808-1.224)
0.968 (0.825-1.136)
AG vs. GG
N
3
0.357
0.223
1.112 (0.932-1.327)
1.112 (0.937-1.321)
AG+AA vs. GG
Overall
5
0.071
0.434
0.210
1.075 (0.897-1.287)
1.038 (0.927-1.162)
AG+AA vs. GG
CRC
3
0.149
0.116
1.158 (0.897-1.496)
1.140 (0.968-1.342)
AG+AA vs. GG
European
3
0.051
0.551
1.072 (0.852-1.350)
1.039 (0.915-1.180)
AG+AA vs. GG
PB
3
0.069
0.581
1.093 (0.798-1.497)
0.983 (0.845-1.144)
AG+AA vs. GG
N
3
0.149
0.116
1.158 (0.897-1.287)
1.140 (0.968-1.342)
AA vs. AG+GG
Overall
5
0.053
0.245
0.180
1.209 (0.878-1.666)
1.117 (0.921-1.355)
AA vs. AG+GG
CRC
3
0.189
0.109
1.280 (0.861-1.903)
1.261 (0.949-1.676)
AA vs. AG+GG
European
3
0.022
0.316
1.268 (0.797-2.019)
1.139 (0.912-1.422)
AA vs. AG+GG
PB
3
0.046
0.396
1.264 (0.736-2.169)
1.054 (0.820-1.355)
AA vs. AG+GG
N
3
0.189
0.109
1.280 (0.861-1.903)
1.261 (0.949-1.676)
PCa: prostate cancer; BC: breast cancer; CRC: colorectal cancer; HWE: Hardy-Weinberg Equilibrium; Y: study conformed to HWE; N: study did not conform to HWE; P-B: population-based; H-B: hospital-based; = value of Egger test; = value of heterogeneity test; = value of Z test.
