Antitumor Effect of Lenvatinib Combined with Alisertib in Hepatocellular Carcinoma by Targeting the DNA Damage Pathway

Figure 1

AURKA was upregulated in HCC tissues. (a) Immunohistochemistry staining for AURKA in HCC tissues and ChC tissues. (b) A colored bar plot displays the number of variant classifications. (c) Variants of per-sample mutation burden. The stacked bar plot shows the variants of each sample in the HCC groups according to mutation classification. (d) Stacked bar plot depicting the variant types of the top 10 mutated genes sorted by decreasing frequency in the HCC groups. (e) Scatterplot of DNA mutation enrichment (-axis) and gene expression (-axis) in hepatic carcinoma and cholangiocarcinoma patients. The enrichment (dashed line) level is represented as the difference in mutation gene enrichment frequency between the two indicated gene expression levels. The -axis shows the log2 AURKA expression for each mutated gene obtained from the intensity of AURKA and the range of AURKA. The red color represents germline mutation, and the blue color represents somatic mutation.

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