Formulation and Quality Control of Orally Disintegrating Tablets (ODTs): Recent Advances and Perspectives

Table 2

Approved excipients used in ODT formulation.

Ingredient type	Example	Role	Ref.
Superdisintegrant	Crospovidone, croscarmellose sodium, sodium starch glycolate, sodium carboxymethyl cellulose, microcrystalline cellulose, spray-dried lactose, acrylic acid, alginic acid, sodium alginate, soy polysaccharides, Isphagula husk pregelatinized starch, modified corn starch, ion exchange resins, gas evolving disintegrants	(i) Burst disintegration facilitator	[4]
Bulking material	Sugar and sugar-based derivatives (dextrose, fructose, isomalt, lactilol, maltitol, maltose, mannitol, sorbitol, starch hydrolysate, polydextrose, and xylitol)	(i) Textural properties (disintegration time) improver	[29]
Emulsifier	Alkyl sulfates, propylene glycol, lecithin, sucrose esters, sodiumdoecylsulfate, sodium lauryl sulfate, polyoxyethylene sorbitan fatty acid esters (Tweens)	(i) Disintegration accelerator; (ii) Bioavailability enhancer of immiscible substances	[30]
Sweetener	Sodium saccharin, sugar alcohols, natural sugars (sugar, dextrose, fructose), sugars derivatives, aspartame, vanilla, bubble gum, grapefruit	(i) Bitter taste mask; (ii) Tablets’ acceptability enhancer	[22]
Flavor	Peppermint flavor, clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, oil of bitter almonds, vanilla, citrus oils, fruit essences	(i) Patient compliance and acceptability improver	[31]