CDCA3 Is a Novel Prognostic Biomarker Associated with Immune Infiltration in Hepatocellular Carcinoma
Table 2
Correlation of CDCA3 mRNA expression and prognosis in hepatocellular carcinoma with different clinicopathologic features by the Kaplan–Meier plotter.
Clinicopathologic features
Overall survival
Progression-free survival
Hazard ratio
value
Hazard ratio
value
Sex
Female
118
2.17 (1.24-3.81)
0.0058
121
2.19 (1.25-3.84)
0.0052
Male
246
1.81 (1.15-2.84)
0.0095
249
1.76 (1.21-2.54)
0.0024
Stage
I
170
1.95 (0.97-3.89)
0.055
171
1.64 (1-2.71)
0.049
II
83
4.39 (1.5-12.83)
0.0031
84
1.76 (0.92-3.37)
0.082
I+II
253
2.33 (1.32-4.11)
0.0026
254
1.52 (1.04-2.23)
0.029
II+III
166
2.56 (1.51-4.34)
0.00031
167
1.95 (1.23-3.1)
0.0041
III
83
2.32 (1.27-4.22)
0.0047
83
2.05 (1.09-3.86)
0.022
III+IV
87
2.18 (1.22-3.9)
0.0074
88
2.18 5(1.17-4.08)
0.012
V
4
—
—
5
—
—
Grade
1
55
4.97 (1.73-14.25)
0.0013
55
2.8 (1.16-6.79)
0.019
2
174
1.97 (1.13-3.44)
0.015
175
2.15 (1.39-3.34)
0.00044
3
118
2.22 (1.21-4.09)
0.0085
119
1.67 (0.99-2.83)
0.051
4
12
—
—
12
—
—
AJCC_T
1
180
1.87 (0.98-3.56)
0.055
180
1.63 (1-2.65)
0.047
2
90
3.69 (1.4-9.7)
0.0047
92
1.99 (1.07-3.69)
0.026
3
78
2.31 (1.25-4.25)
0.0059
78
2.25 (1.08-4.68)
0.026
4
13
—
—
13
—
—
Vascular invasion
None
203
2.09 (1.14-3.81)
0.015
204
1.47 (0.94-2.3)
0.089
Micro
90
2.15 (0.86-5.35)
0.092
91
1.57 (0.85-2.9)
0.14
Macro
16
—
—
16
—
—
Race
White
181
2.48 (1.27-4.84)
0.0059
183
2.02 (1.29-3.14)
0.0016
Black or African man
17
—
—
17
—
—
Asian
155
3.01 (1.57-5.76)
0.00048
155
1.91 (1.18-3.08)
0.007
Alcohol consumption
Yes
115
1.41 (0.75-2.67)
0.29
115
1.97 (1.17-3.34)
0.0099
None
202
1.63 (1.03-2.59)
0.037
204
1.47 (0.98-2.19)
0.06
Virus hepatitis
Yes
150
1.19 (0.62-2.27)
0.6
152
0.96 (0.61-1.52)
0.86
None
167
2.18 (1.37-3.45)
0.00073
167
2.67 (1.69-4.21)
Note: represents the numbers of patients with different clinicopathologic features; the hazard ratio represents the higher risk factors produced by high CDCA3 expression affected in the prognosis of patients with different clinicopathologic features; clinicopathologic features include stage, grade, AJCC_T, vascular invasion, gender, race, sorafenib treatment, alcohol consumption, and hepatitis virus; bold values indicate ; was statistically significant.
