CDCA3 Is a Novel Prognostic Biomarker Associated with Immune Infiltration in Hepatocellular Carcinoma

Table 3

Correlation analysis between CDCA3 and related genes and markers of immune cells in TIMER.

Description	Gene markers	HCC
		None		Purity
		Partial cor	value	Partial cor	value
CD8+ T cell	CD8A	0.189		0.294
	CD8B	0.225		0.326
T cell (general)	CD3D	0.318		0.435
	CD3E	0.194		0.344
	CD2	0.209		0.347
B cell	CD19	0.243		0.319
	CD79A	0.154		0.266
Monocyte	CD86	0.259		0.395
	CD115	0.109	0.0366	0.228
TAM	CCL2	-0.001	0.979	0.079	0.141
	CD68	0.208		0.288
	IL10	0.182		0.281
M1 macrophage	iNOS	0.226		0.274
	IRF5	0.362		0.372
	COX2	-0.009	0.86	0.089	0.0996
M2 macrophage	CD163	-0.004	0.935	0.077	0.154
	VSIG4	0.035	0.498	0.117	0.0303
	MS4A4A	0.023	0.656	0.125	0.0201
Neutrophils	CD66b	0.102	0.05	0.126	0.0189
	CD11b	0.243		0.32
	CCR7	0.036	0.493	0.163
Natural killer cell	KIR2DL1	-0.023	0.665	-0.036	0.504
	KIR2DL3	-0.158		0.2
	KIR2DL4	0.216		0.247
	KIR3DL1	-0.008	0.88	0.005	0.924
	KIR3DL2	0.095	0.0662	0.129	0.0162
	KIR3DL3	0.076	0.143	0.097	0.0728
	KIR2DS4	0.051	0.332	0.046	0.398
Dendritic cell	HLA-DPB1	0.143		0.25
	HLA-DQB1	0.147		0.245
	HLA-DRA	0.131	0.0117	0.236
	HLA-DPA1	0.095	0.0684	0.203
	BDCA-1	0.071	0.175	0.159
	BDCA-4	0.121	0.0199	0.141
	CD11c	0.285		0.408
Th1	T-bet	0.069	0.185	0.175
	STAT4	0.21		0.271
	STAT1	0.286		0.335
	IFN-γ	0.278		0.353
	TNF-α	0.216		0.34
Th2	GATA3	0.155		0.274
	STAT6	0.005	0.926	0.005	0.931
	STAT5A	0.212		0.254
	IL13	0.084	0.107	0.094	0.0807
Tfh	BCL6	0.071	0.172	0.075	0.163
	IL21	0.129	0.0132	0.171
Th17	STAT3	-0.023	0.657	0.003	0.963
	IL17A	0.081	0.12	0.1	0.0639
Treg	FOXP3	0.094	0.0713	0.174
	CCR8	0.27		0.352
	STAT5B	0.092	0.0763	0.077	0.155
	TGFβ (TGFB1)	0.259		0.351
Exhausted T cells	PD-1 (PDCD-1)	0.347		0.454
	CTLA4	0.362		0.474
	LAG3	0.364		0.415
	TIM3 (HAVCR2)	0.284		0.427
	GZMB	0.111	0.0327	0.186

HCC: hepatocellular carcinoma; TAM: tumor-associated macrophage; Th1: T-helper 1 cells; Th2: T-helper 2 cells; Th17: T-helper 17 cells; Tfh: follicular helper T cell; Treg: regulatory T cell. Note: partial cor (partial correlation coefficient) represents the correlation coefficient between the CDCA3 expression and gene markers of infiltrating immune cells; purity represents the correlation adjusted by purity; none represents the correlation without adjustment; , , and .