In Vivo Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma by Autologous Whole Tumor Dead Cells

Figure 7

ICBs-CT26 protect mice against CT26 tumor. (a) Schematic representation of the immunization protocol. BALB/c mice were immunized with ICBs-CT26 every seven days for three weeks. One week after the final immunization, the animals were challenged with live CT26 cells. (b) Tumor was evaluated daily, and its appearance was graphed with Kaplan-Meier with % tumor appearance curves in ICBs-CT26 immunized animals (green circles) and control animals (black circles; vehicle is PBS). (c) CT26-tumor growth of control and immunized animals with ICBs-CT26 that developed tumor. The grey line represents animals with complete tumor regression. Tumor growth was measured in all groups of animals when tumor size in the control group reached its maximum. The tumor size was evaluated with the two-tailed Fisher exact test and using contingency tables. The asterisks () represent statistically significant effects (). .

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