Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis

<div>The crystal structure of TGF-<i>β</i>1 in complex with silmitasertib. (a) A cartoon representation of the TGF-<i>β</i>1-silmitasertib complex. (b) Surface representation of TGF-<i>β</i>1. Silmitasertib is represented in red-colored sticks. (c) A zoomed view of substrate-binding pocket representing the key amino acid residues forming interactions with inhibitor molecule. (d) Surface representation of conserved substrate-binding pocket of TGF-<i>β</i>1.</div>

BioMed Research International

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Figure 1

Figure 1: Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis 

Figure 1 | Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis 