Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis

<div>Structural dynamics of TGF-β1 up on silmitasertib binding. (a) The RMSD plot of TGF-β1 as a function of time. (b) RMSF plot of free TGF-β1 and upon silmitasertib binding. (c) Time evolution of radius of gyration. (d) The SASA plot of TGF-β1 as a function of time. The values were obtained from 100 ns MD simulations time scale. Black and blue represent values obtained for free TGF-β1 and the TGF-β1-silmitasertib complex, respectively.</div>

BioMed Research International

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Figure 2

Figure 2: Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis 

Figure 2 | Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis 