Small Molecule “Silmitasertib” Repurposed as Inhibitor of Transforming Growth Factor Beta 1 for the Development of Therapeutics for Oral Submucous Fibrosis

Table 1

Binding parameters of selected small drug molecules with TGF-β1.

S. No.	Small drug molecules	Target protein	Binding affinity (kcal/mol)	Inhibition constant, (nM)
1	Silmitasertib	TGF-β1	-9.3	1.61889E-06
2	SR10067		-7.8	1.91655E-06
3	Neoruscogenin		-7.5	3.17997E-06
4	SR1078		-7.3	4.45681E-06
5	SRT2183		-7.3	4.45681E-06