Long Noncoding RNA RP11-357H14.17 Plays an Oncogene Role in Gastric Cancer by Activating ATF2 Signaling and Enhancing Treg Cells

Figure 3

RP11-357H14.17 promotes the malignancy by promoting ATF2 signaling in human gastric cancer. Heatmap of all significantly different gene sets of c6 ssGSEA analysis for comparison between cancer and normal control samples (a) and RP11-357H14.17 high and low expression samples (b) from TCGA-STAD. ATF2-related gene sets were highlighted with red font (c). Heatmap of up-regulated genes in “ATF2_up.v1_DN” gene set derived from comparison between cancer and normal control samples and RP11-357H14.17 high and low expression samples from TCGA-STAD. The representative genes stand for “ATF2_up.v1_DN” gene set were highlighted in bold. (d) Representative gene expression stands for “ATF2_up.v1_DN” gene set was compared between cancer and normal control samples, RP11-357H14.17 high and low expression samples from TCGA-STAD, , , and , by unpaired test, and 52 paired GC tissues categorized as RP11-357H14.17 high, low expression, and normal control, , one-way ANOVA (e). (f) Representative IHC staining figures for ATF2 and WT1 protein and comparison between 52 paired GC tissues categorized as RP11-357H14.17 high, low expression, and normal control, , one-way ANOVA.

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