The Possible Role of Vitamin D Deficiency in Early Implant Failure

Table 2

Animal studies about the relation between vitamin D and early implant failure.

Author name	Country	Sample size	Result	Conclusion	Reference
Salomo-Coll et al., 2015	Spain	24 dogs	No statistically differences could be found between the two groups	With the limitation of animal studies, topical application of vitamin D on dental implants could reduce crestal bone loss and increase 10% more bone-to-implant contact at a 12-week follow-up period	[49]
Naito et al., 2014	Brazil	28 rabbits	The 1.25-(OH)2D3-coated implants tended to osseointegrate better than the noncoated surfaces. The differences were not significant	Future studies are recommended to investigate a base substrate’s development that can maintain 1.25-(OH) 2D3 for a long period	[24]
Cho et al., 2011	Korea	12 rabbits	A significant relationship was found between the case and control groups	This study demonstrated that the PLGA/1α,25-(OH)2D3 solution coating resulted in submicron-sized particles, which may stimulate bone formation adjacent to the surface of implants inserted into bone	[50]