Computer-Aid Directed Evolution of GPPS and PS Enzymes

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Interaction mode</td><td class="align_center">Key site in GPPS</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left" rowspan="3">Hydrogen bond in solution</td><td class="align_center">H167</td></tr><tr><td class="align_center">R138</td></tr><tr><td class="align_center">T273</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_left" rowspan="2">Strongly hydrophobic interaction</td><td class="align_center">L171</td></tr><tr><td class="align_center">I252</td></tr><tr><td class="align_center" colspan="2"><hr/></td></tr><tr><td class="align_left" rowspan="9">Weak hydrophobic interaction</td><td class="align_center">R185</td></tr><tr><td class="align_center">R186</td></tr><tr><td class="align_center">I244</td></tr><tr><td class="align_center">K272</td></tr><tr><td class="align_center">I268</td></tr><tr><td class="align_center">K327</td></tr><tr><td class="align_center">K331</td></tr><tr><td class="align_center">K337</td></tr><tr><td class="align_center">D170</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Key sites for IPP interaction of GPPS and their interaction modes.</div>

BioMed Research International

tab1

Table 1

Table 1: Computer-Aid Directed Evolution of GPPS and PS Enzymes 