Upregulation of CDC7 Associated with Cervical Cancer Incidence and Development

Figure 6

Characteristics and expression of CDC7 in cervical cancer. Immunohistochemistry showed that CDC7 was differentially expressed in (a) normal cervical epithelial tissues and (b) cervical cancer tissues. qRT-PCR detection shows the expression of CDC7 in cervical cancer tissues and in the human normal cervical epithelial tissues. (c) The data are denoted by . vs. human normal cervical epithelial tissues. qRT-PCR detection shows the expression of CDC7 in siCDC7 and siNC transfected cervical cancer cell lines (Hela and SiHa). (d) The data are denoted by . vs. NC. Downregulation CDC7 suppressed cell proliferation. (e, f) Cell counting kit-8 (CCK-8) detection shows the cell proliferation of both (e) HeLa and (f) SiHa cells. The data are denoted by . and vs. NC. Downregulation CDC7 suppressed cell invasion and promotes cell apoptosis. (g–j) Flow cytometry detection shows the cell apoptosis of both (g, h) HeLa and (i, j) SiHa cells. The data are denoted by . and vs. NC. (k–n) Shows the cell invasion of both (k, l) HeLa and (m, n) SiHa cells. The data are denoted by . and vs. NC.

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