[Retracted] Agomelatine Softens Depressive-Like Behavior through the Regulation of Autophagy and Apoptosis

Figure 2

Effect of AGO treatment on BDNF/TrkB and pERK1/2 in autophagy, apoptosis, and inflammation in CRS mice. (a) Representative western blot results of BDNF, TrkB, and pERK1/2 are shown; densitometry analysis of BDNF (b), TrkB (c), and pERK1/2 (d) in the hippocampus is presented. (e) Representative western blot results of LC3II, Beclin1, and p62 are shown; densitometry analysis of Beclin1 (f), LC3II (g), and p62 (h) in the hippocampus. (i) Representative western blot results of Bcl2 and Bax are shown; (j) densitometry analysis of the Bcl2/Bax ratio in the hippocampus. (k) Representative western blot results of NF-κB/p65, iNOS, and nNOS; densitometry analysis of NF-κB/p65 (l), iNOS (m), and nNOS (n) in the hippocampus. ; ; ; ns = not significant. The values represent . -5.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)

(n)