TCF7L1 Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population

Table 4

Association analysis between TCF7L1 SNPs and cervical cancer risk.

SNP ID	Model	Genotype	Case	Control	Without adjusted		With adjusted
					OR (95% CI)	^a	OR (95% CI)	^b
rs11904127	Allele	G	644	564			1
		A	368	408			0.79 (0.66-0.95)	0.010
	Codominant	GG	209	157	1		1
		GA	226	250	0.68 (0.52-0.89)	0.006	0.68 (0.52-0.89)	0.006
		AA	71	79	0.68 (0.46-0.99)	0.044	0.67 (0.46-0.99)	0.043
	Dominant	GG	209	157	1		1
		AG-AA	297	329	0.68 (0.52-0.88)	0.003	0.68 (0.52-0.88)	0.003
	Recessive	GG-AG	435	407	1		1
		AA	71	79	0.84 (0.59-1.19)	0.329	0.84 (0.59-1.19)	0.323
	Log-additive	—	—	—	0.79 (0.66-0.95)	0.010	0.79 (0.66-0.94)	0.010
rs2366264	Allele	G	716	677			1
		T	298	309			0.91 (0.75-1.10)	0.343
	Codominant	GG	249	233	1		1
		GT	218	211	0.97 (0.75-1.25)	0.799	0.97 (0.74-1.25)	0.797
		TT	40	49	0.76 (0.49-1.20)	0.245	0.76 (0.48-1.20)	0.244
	Dominant	GG	249	233	1		1
		TG-TT	258	260	0.93 (0.72-1.19)	0.558	0.93 (0.72-1.19)	0.556
	Recessive	GG-TG	467	444	1		1
		TT	40	49	0.78 (0.50-1.20)	0.256	0.78 (0.50-1.20)	0.256
	Log-additive	—	—	—	0.91 (0.75-1.10)	0.340	0.91 (0.75-1.10)	0.338
rs11689667	Allele	T	719	674			1
		C	293	312			0.88 (0.73-1.07)	0.191
	Codominant	TT	253	230	1		1
		TC	213	214	0.90 (0.70-1.17)	0.452	0.90 (0.70-1.17)	0.447
		CC	40	49	0.74 (0.47-1.17)	0.198	0.74 (0.47-1.17)	0.198
	Dominant	TT	253	230	1		1
		TC-CC	253	263	0.87 (0.68-1.12)	0.290	0.87 (0.68-1.12)	0.287
	Recessive	TT-TC	466	444	1		1
		CC	40	49	0.78 (0.50-1.21)	0.260	0.78 (0.50-1.21)	0.261
	Log-additive	—	—	—	0.88 (0.73-1.07)	0.188	0.88 (0.72-1.07)	0.187
rs62162674	Allele	G	711	654			1
		C	301	336			0.82 (0.68-0.99)	0.044
	Codominant	GG	245	210	1		1
		GC	221	234	0.81 (0.62-1.05)	0.112	0.81 (0.62-1.05)	0.107
		CC	40	51	0.67 (0.43-1.06)	0.086	0.67 (0.43-1.06)	0.085
	Dominant	GG	245	210	1		1
		CG-CC	261	285	0.79 (0.61-1.01)	0.057	0.78 (0.61-1.01)	0.054
	Recessive	GG-CG	466	444	1		1
		CC	40	51	0.75 (0.48-1.15)	0.188	0.75 (0.48-1.15)	0.189
	Log-additive	—	—	—	0.82 (0.67-0.99)	0.039	0.81 (0.67-0.99)	0.038

CI: confidence interval; OR: odds ratio; SNP: single nucleotide polymorphism. ^a values were calculated by logistic regression analysis without adjustment. ^b values were calculated by logistic regression analysis with adjustment for age. indicates statistical significance.