TCF7L1 Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population

Table 5

The association of TCF7L1 SNPs with the risk of cervical cancer stratified by age.

SNP	Model	Allele/genotype	Case	Control	OR (95% CI)		Case	Control	OR (95% CI)
Age			> 51				≤ 51
rs11904127	Allele	G	327	268	1		317	296	1
		A	185	206	0.74 (0.57-0.95)	0.019	183	202	0.85 (0.66-1.09)	0.199
	Codominant	GG	108	76	1		101	81	1
		GA	111	116	0.67 (0.46-0.99)	0.049	115	134	0.69 (0.47-1.01)	0.056
		AA	37	45	0.58 (0.34-0.98)	0.040	34	34	0.80 (0.46-1.40)	0.435
	Dominant	GG	108	76	1		101	81	1
		AG-AA	148	161	0.65 (0.45-0.94)	0.021	149	168	0.71 (0.49-1.03)	0.068
	Recessive	GG-AG	219	192	1		216	215	1
		AA	37	45	0.72 (0.45-1.16)	0.173	34	34	0.99 (0.60-1.66)	0.982
	Log-additive	—	—	—	0.74 (0.58-0.96)	0.021	—	—	0.84 (0.64-1.09)	0.186
rs2366264	Allele	G	365	317	1		351	360	1
		T	147	159	0.80 (0.61-1.05)	0.111	151	150	1.03 (0.79-1.35)	0.816
	Codominant	GG	129	108	1		120	125	1
		GT	107	101	0.89 (0.61-1.29)	0.531	111	110	1.05 (0.73-1.51)	0.793
		TT	20	29	0.58 (0.31-1.08)	0.083	20	20	1.05 (0.54-2.04)	0.898
	Dominant	GG	129	108	1		120	125	1
		TG-TT	127	130	0.82 (0.57-1.17)	0.265	131	130	1.05 (0.74-1.49)	0.787
	Recessive	GG-TG	236	209	1		231	235	1
		TT	20	29	0.61 (0.33-1.11)	0.104	20	20	1.02 (0.53-1.95)	0.950
	Log-additive	—	—	—	0.80 (0.61-1.05)	0.113	—	—	1.03 (0.79-1.36)	0.810
rs11689667	Allele	T	366	315	1		353	359	1
		C	146	161	0.78 (0.60-1.02)	0.072	147	151	0.99 (0.76-1.30)	0.942
	Codominant	TT	130	106	1		123	124	1
		TC	106	103	0.84 (0.58-1.22)	0.360	107	111	0.97 (0.67-1.40)	0.873
		CC	20	29	0.56 (0.30-1.05)	0.069	20	20	1.01 (0.52-1.97)	0.975
	Dominant	TT	130	106	1		230	235	1
		TC-CC	126	132	0.78 (0.55-1.11)	0.165	123	124	0.98 (0.69-1.39)	0.895
	Recessive	TT-TC	236	209	1		127	131	1
		CC	20	29	0.61 (0.33-1.11)	0.103	20	20	1.03 (0.54-1.96)	0.941
	Log-additive	—	—	—	0.78 (0.60-1.02)	0.073	—	—	0.99 (0.75-1.30)	0.942
rs62162674	Allele	G	362	303	1		349	351	1
		C	150	175	0.72 (0.55-0.94)	0.014	151	161	0.94 (0.72-1.23)	0.668
	Codominant	GG	126	94	1		119	116	1
		GC	110	115	0.72 (0.49-1.04)	0.081	111	119	0.91 (0.63-1.31)	0.600
		CC	20	30	0.50 (0.27-0.93)	0.028	20	21	0.93 (0.48-1.81)	0.839
	Dominant	GG	126	94	1		119	116	1
		CG-CC	130	145	0.67 (0.47-0.96)	0.028	131	140	0.91 (0.64-1.29)	0.602
	Recessive	GG-CG	236	209	1		230	235	1
		CC	20	30	0.59 (0.32-1.07)	0.080	20	21	0.98 (0.52-1.86)	0.947
	Log-additive	—	—	—	0.71 (0.54-0.93)	0.014	—	—	0.94 (0.71-1.24)	0.659

values were calculated by logistic regression adjusted by age. indicates statistical significance.