Safety Evaluation of Standardized Extract of Curcuma longa (NR-INF-02): A 90-Day Subchronic Oral Toxicity Study in Rats

Table 1

Group mean feed consumption (g/day/animal) of male rats administered with NR-INF-02 daily for 90 days.

Weeks	Control and control recovery	250 mg/kg		500 mg/kg		1000 mg/kg and 1000 mg/kg recovery
	Average	Average	% of control	Average	% of control	Average	% of control
1	19.49	19.39	100	19.85	102	20.29	104
2	22.22	22.24	100	23.06	104	23.16	104
3	23.17	22.99	99	24.06	104	23.71	102
4	23.61	23.87	101	25.07	106	23.54	100
5	24.02	23.53	98	24.98	104	23.57	98
6	24.36	23.91	98	25.9	106	24.86	102
7	24.14	23.82	99	24.81	103	24.03	100
8	24.45	24.55	100	26.85	110	25.13	103
9	25.24	24.73	98	26.6	105	25.6	101
10	24.01	23.83	99	24.86	104	24.22	101
11	24.03	23.5	98	25.58	106	22.7	94
12	23.59	22.85	97	24.5	104	22.93	97
13	22.72	19.91	88	20.46	90	20.73	91
14	23.05	—	—	—	—	22.65	98
15	24.16	—	—	—	—	23.24	96
16	24.41	—	—	—	—	23.39	96
17	25.00	—	—	—	—	24.89	100
Study average	23.46	23.01	98.06	24.35	103.70	23.42	99.86
Recovery average	24.16					23.54	97.46