Safety Evaluation of Standardized Extract of Curcuma longa (NR-INF-02): A 90-Day Subchronic Oral Toxicity Study in Rats

Table 5

Clinical chemistry data () of male rats after oral administration of NR-INF-02 for 90 days.

Parameter	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control recovery	1000 mg/kg recovery
ALT (U/L)
AST (U/L)
Albumin (g/dL)
ALP (U/L)
Total protein (g/dL)
Urea (mg/dL)
Bile acid (μmol/L)
Cholesterol (mg/dL)
Calcium (mg/dL)
CK-Nac (U/L)
Creatinine (mg/dL)
Glucose (mg/dL)
GGT (U/L)
LDH (U/L)
Phosphorus (mg/dL)						^#↓
Triglyceride (mg/dL)			↑
Total bilirubin (mg/dL)
BUN (mg/dL)
A/G ratio
Globulin (g/dL)						^#↓
HDL (mg/dL)
LDL (mg/dL)
Na (mmol/L)			↑
K (mmol/L)
Cl (mmol/L)						^#↑

versus the control group; ^# versus the control recovery group; ↑: increase; ↓: decrease.