Purinergic Signaling Mediates PTH and Fluid Flow-Induced Osteoblast Proliferation

<div>P2Y2 purinergic receptors are involved in PTH and oscillatory fluid flow-induced osteoblast responses. (a) Knockdown of P2Y2 inhibits ERK1/2 phosphorylation while the overexpression of P2Y2 enhances ERK1/2 phosphorylation. (b) Knockdown of P2Y2 inhibits CREB phosphorylation while the overexpression of P2Y2 enhances CREB phosphorylation. 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BioMed Research International

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Figure 4

Figure 4: Purinergic Signaling Mediates PTH and Fluid Flow-Induced Osteoblast Proliferation 