Plasma-Derived Exosomal hsa-miR-4488 and hsa-miR-1228-5p: Novel Biomarkers for Dermatomyositis-Associated Interstitial Lung Disease with Anti-Melanoma Differentiation-Associated Protein 5 Antibody-Positive Subset

<div>Comparison between identified miRNAs released from exosomes of DM-ILD-MDA5 Ab(+), DM-nonILD-MSA16(-), and HC. Venn diagram demonstrating that the homologous exosomes from three comparisons have two common miRNAs (hsa-miR-1228-5p and hsa-miR-4488). HC: healthy controls; DM-ILD-MDA5 Ab(+): DM patients with ILDs and anti-melanoma differentiation-associated protein 5 antibody-positive status; DM-nonILD-MSA16(-): DM patients without ILDs who were negative for 16 detectable myositis-specific antibodies; ILD: interstitial lung disease; DM: dermatomyositis; miRNA/miR: microRNA; hsa: <i>Homo sapiens</i>.</div>

BioMed Research International

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Figure 3: Plasma-Derived Exosomal hsa-miR-4488 and hsa-miR-1228-5p: Novel Biomarkers for Dermatomyositis-Associated Interstitial Lung Disease with Anti-Melanoma Differentiation-Associated Protein 5 Antibody-Positive Subset 

Figure 3 | Plasma-Derived Exosomal hsa-miR-4488 and hsa-miR-1228-5p: Novel Biomarkers for Dermatomyositis-Associated Interstitial Lung Disease with Anti-Melanoma Differentiation-Associated Protein 5 Antibody-Positive Subset 