Low REST Expression Indicates a Biomarker of Poor Prognosis in Patients with Renal Cell Carcinoma

Table 2

Associations between the clinicopathologic variables and REST expression.

Parameters	Variables	Numbers	REST					value
			High	Prop (%)	Low	Prop (%)
Age	≥55	362	60	56.60	302	70.73	7.773	0.005
	<55	171	46	43.40	125	29.27
Gender	Male	345	68	64.15	277	64.87	0.0193	0.890
	Female	188	38	35.85	150	35.13
Histologic grade	G1	14	4	3.77	10	2.36	11.006	0.026
	G2	230	52	49.06	178	41.98
	G3	205	39	36.79	166	39.15
	G4	76	8	7.55	68	16.04
	GX	5	3	2.83	2	0.47
Pathologic stage	I	269	67	63.21	202	47.31	10.566	0.014
	II	56	12	11.32	44	10.30
	III	124	16	15.09	108	25.29
	IV	84	11	10.38	73	17.10
M classification	M0	422	95	89.62	327	76.94	11.002	0.004
	M1	79	11	10.38	68	16
	MX	30	0	0	30	7.06
N classification	N0	240	48	45.28	192	44.97	0.7340	0.693
	N1	17	2	1.89	15	3.51
	NX	276	56	52.83	220	51.52
T classification	T1	274	68	64.15	206	48.24	9.267	0.026
	T2	68	12	11.32	56	13.11
	T3	180	24	22.64	156	36.54
	T4	11	2	1.89	9	2.11
Vital status	Dead	161	13	12.26	148	34.66	20.204	0.0001
	Survival	372	93	87.74	279	65.34