Low REST Expression Indicates a Biomarker of Poor Prognosis in Patients with Renal Cell Carcinoma

Table 4

Univariate and multivariate analysis of relapse-free survival in patients with KIRC.

	Univariate analysis			Multivariate analysis
	Hazard ratio	CI95	value	Hazard ratio	CI95	value
Age	1.33	0.93-1.91	0.117
Gender	0.77	0.54-1.10	0.155
Histologic grade	1.97	1.62-2.38	0.0001	1.31	1.04-1.64	0.020
Pathologic stage	2.42	2.07-2.83	0.0001	2.62	1.84-3.80	0.0001
M classification	3.42	2.69-4.34	0.0001	1.08	0.66-1.78	0.762
N classification	1.03	0.87-1.22	0.730
T classification	2.34	1.94-2.83	0.0001	0.73	0.51-1.05	0.092
REST	1.34	1.18-1.52	0.0001	1.21	1.04-1.41	0.014