Research Article
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection
Table 1
Summary of prediction results for nsSNPs in the human ACE2 gene using various bioinformatics tools.
| | SIFT | PolyPhen 2.0 | PROVEAN | PANTHER | | SNPs ID | AA variant | Score | Prediction | Score | Prediction | Score | Prediction | PSPE | Prediction |
| | rs372272603 | R219C | 0 | Del | 1.000 | Pro Dam | -2.483 | Not Del | 750 | Pro Dam | | rs759590772 | R219H | 0 | Del | 0.988 | Pro Dam | -1.520 | Not Del | 750 | Pro Dam | | rs1396769231 | M383T | 0 | Del | 1.000 | Pro Dam | -4.797 | Del | 911 | Pro Dam | | rs762890235 | P389H | 0 | Del | 0.993 | Pro Dam | -7.862 | Del | 1037 | Pro Dam | | rs1316056737 | D427Y | 0 | Del | 0.970 | Pro Dam | -3.390 | Del | 176 | Not Del | | rs1352194082 | R514G | 0.02 | Del | 0.989 | Pro Dam | -6.483 | Del | 1037 | Pro Dam | | rs776995986 | R708W | 0.01 | Del | 1.000 | Pro Dam | -3.105 | Del | 361 | Pos Del | | rs901495523 | R710C | 0 | Del | 1.000 | Pro Dam | -2.936 | Del | 750 | Pro Dam | | rs370187012 | R710H | 0 | Del | 1.000 | Pro Dam | -1.788 | Not Del | 750 | Pro Dam | | rs144869363 | R716C | 0.01 | Del | 0.975 | Pro Dam | -1.638 | Not Del | 220 | Pos Del | | rs759590772 | L731F | 0 | Del | 0.995 | Pro Dam | -1.124 | Not Del | 750 | Pro Dam | | rs372272603 | R768W | 0 | Del | 1.000 | Pro Dam | -2.822 | Del | 750 | Pro Dam |
|
|
AA variant: amino acid variant; Del: deleterious; Not Del: not deleterious; Pro Dam: probably damaging; Pos Dam: possibly damaging; PSPE: position-specific evolutionary preservation.
|
