Research Article
In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection
Table 2
Prediction of effect of nsSNPs on protein stability using I. Mutant Suite.
| | SNPs ID | Amino acid substitution | Stability | RI | DDG value prediction (kcal/mol) |
| | rs372272603 | R219C | Increase | 0 | -0.50 | | rs759590772 | R219H | Decrease | 3 | -0.58 | | rs1396769231 | M383T | Increase | 2 | -0.32 | | rs762890235 | P389H | Increase | 2 | 0.20 | | rs1316056737 | D427Y | Decrease | 3 | -0.56 | | rs1352194082 | R514G | Decrease | 8 | -1.84 | | rs776995986 | R708W | Decrease | 4 | -0.68 | | rs901495523 | R710C | Decrease | 8 | -1.72 | | rs370187012 | R710H | Decrease | 9 | -1.91 | | rs144869363 | R716C | Decrease | 7 | -2.20 | | rs759590772 | L731F | Increase | 4 | 0.01 | | rs372272603 | R768W | Decrease | 0 | -0.55 |
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RI: reliability index; DDG: the free energy change value.
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