In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection

Table 6

Data generated from SWISS-MODEL.

SNPs	QMEAN	CBeta interaction energy	All-atom pairwise energy	Solvation energy	Torsion energy
D427Y	-1.09	1.08	1.05	0.76	-1.52
R514G	-1.27	0.39	0.78	0.52	-1.50
R708W	-1.28	0.33	0.70	0.52	-1.50
R710C	-1.37	0.34	0.74	0.42	-1.55
R716C	-1.33	0.42	0.76	0.45	-1.54
R768W	-1.09	1.01	1.05	0.74	-1.50

CBeta interaction energy: distance-dependent potential using CBeta atoms as interaction center; All-atom pairwise energy: assessment of long-range interactions; Solvation energy: description of the burial status of the residues; Torsion energy: analysis of the local backbone geometry [32].