Antitumor Effect of Inula viscosa Extracts on DMBA-Induced Skin Carcinoma Are Mediated by Proteasome Inhibition

Figure 5

Hematoxylin and eosin staining of cross-sections of mouse skin and observed under light microscope. (a) Skin of control mice treated with the vehicle shows a normal distribution of the deferent skin layer. (b) Carcinogenesis group (DMBA/croton oil) showed epithelial vascular lesion, epidermal hyperplasia with hyperkeratosis, tumor nest, parakeratosis, spongiosis, and marked acanthosis. (c) Mouse skin treated with Inula viscosa extract showed normal skin structure and architecture with mild to moderate prevention of skin carcinogenesis.

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