Research Article
Antitumor Effect of Inula viscosa Extracts on DMBA-Induced Skin Carcinoma Are Mediated by Proteasome Inhibition
Table 5
Pharmacokinetics and toxicity evaluation of compounds from Inula viscosa.
| | Inuviscolide | Isocosticacid | Tomentosin | Carfilzomib |
| | Absorption and distribution | | Blood-brain barrier (LogBB) | 0.018 | 0.341 | 0.14 | -1.082 | | Intestinal absorption (human) | 97.306 | 93.881 | 97.922 | 55.371 | | Caco-2 permeability | 1.288 | 1.593 | 1.343 | 0.056 | | Metabolism | | Substrate CYP2D6 | No | No | No | No | | Substrate CYP3A4 | No | Yes | No | Yes | | Inhibitor CYP1A2 | No | No | No | No | | Inhibitor CYP2C9 | No | No | No | No | | Inhibitor CYP2D6 | No | No | No | No | | Inhibitor CYP2C19 | No | No | No | No | | Inhibitor CYP3A4 | No | No | No | Yes | | Excretion and toxicity | | Clearance | 1.057 | 1.162 | 1.276 | 1.027 | | AMES toxicity | No | No | No | No | | Carcinogens | No | No | No | No |
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