RBM23 Drives Hepatocellular Carcinoma by Activating NF-κB Signaling Pathway

Figure 1

Expression levels of RBM23 positively correlated with MVD in HCC tissues. (a) Western blot analysis of the expression of RBM23 and CD31 in paired tumor tissues and matched normal tissues; GAPDH was used as a loading control. (b) IHC staining indicating higher RBM23 protein expression in HCC tissues than in normal liver tissues. The expression showed a high positive correlation with MVD (as indicated by CD31-positive cells) (1 cm represents 100 μm). (c) Differences in RBM23 expression between different tumor cells. (d) The western blotting assays showing overexpression and knockdown of RBM23 in Huh-7 cells and HepG2 cells, respectively (left); RBM23 overexpression in Huh-7 cells promoted HUVEC tube formation whereas RBM23 knockdown in HepG2 cells inhibited HUVEC tube formation (right).

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