Research Article
Pharmacokinetic Study of Safrole and Methyl Eugenol after Oral Administration of the Essential Oil Extracts of Asarum in Rats by GC-MS
Table 4
Stability of 2 analytes in rat plasma (
).
| Compounds | Spiked concentration (ng/mL) | Room temperature for 4 h | Three freeze-thaw cycles | Auto-sampler for 12 h | -80°C for 7 days | Measured concentration (ng/mL) | RSD (%) | Measured concentration (ng/mL) | RSD (%) | Measured concentration (ng/mL) | RSD (%) | Measured concentration (ng/mL) | RSD (%) |
| Safrole | 120 | | 9.3 | | 7.8 | | 8.7 | | 8.2 | 1200 | | 1.2 | | 1.6 | | 0.3 | | 3.1 | 12000 | | 0.3 | | 2.7 | | 1.8 | | 0.8 | Methyl eugenol | 80 | | 9.9 | | 8.2 | | 8.2 | | 6.5 | 800 | | 1.0 | | 2.3 | | 0.8 | | 5.4 | 8000 | | 0.9 | | 7.2 | | 3.2 | | 8.7 |
|
|