Prognostic Factors and a Nomogram Predicting Overall Survival and Cancer-Specific Survival for Patients with Collecting Duct Renal Cell Carcinoma

Table 2

Univariate and multivariate Cox regression models associated with overall survival.

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI		HR	95% CI
Sex
Male	Ref
Female	0.903	0.689~1.183	0.460
Age	1.012	1.003~1.022	0.011	1.016	1.006~1.026	0.002
Marital status
Unmarried	Ref
Married	1.126	0.862~1.472	0.383
Race
White	Ref
Black	0.861	0.635~1.168	0.336
Others	1.038	0.638~1.689	0.881
Tumor size	1.031	1.017~1.044	<0.001	1.002	1.000~1.004	0.014
Tumor side
Left	Ref
Right	1.191	0.929~1.527	0.168
Tumor grade
G1	Ref			Ref
G2	1.798	0.532~6.078	0.345	1.139	0.333~3.901	0.836
G3	4.580	1.449~14.479	0.010	2.090	0.645~6.771	0.219
G4	5.255	1.650~16.737	0.005	2.722	1.002~8.895	0.043
Gx	4.995	1.564~15.955	0.007	2.066	0.628~6.799	0.232
T stage
T1	Ref			Ref
T2	1.328	0.757~2.328	0.322	NA	NA	0.675
T3	2.308	1.711~3.113	<0.001	NA	NA	0.107
T4	3.475	2.191~5.512	<0.001	NA	NA	0.399
Tx	4.192	1.514~11.607	0.006	NA	NA	0.355
N stage
N0	Ref			Ref
N1	2.591	1.986~3.379	<0.001	1.645	1.202~2.252	0.002
Nx	3.894	2.027~7.480	<0.001	2.549	1.187~5.475	0.016
M stage
M0	Ref			Ref
M1	4.115	3.141~5.390	<0.001	3.724	2.623~5.288	<0.001
Mx	5.183	1.900~14.135	<0.001	1.141	0.350~3.724	0.827
Surgical type
Without	Ref			Ref
NSS	0.078	0.035~0.176	<0.001	0.224	0.094~0.535	0.001
RN	0.312	0.222~0.438	<0.001	0.515	0.339~0.781	0.002
Radiotherapy
Without	Ref			Ref
With	2.238	1.561~3.208	<0.001	NA	NA	0.822
Chemotherapy
Without	Ref			Ref
With	1.725	1.313~2.268	<0.001	0.512	0.357~0.735	0.014