Prognostic Factors and a Nomogram Predicting Overall Survival and Cancer-Specific Survival for Patients with Collecting Duct Renal Cell Carcinoma

Table 3

Univariate and multivariate Cox regression models associated with cancer-specific survival.

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI		HR	95% CI
Sex
Male	Ref
Female	0.808	0.597~1.092	0.165
Age	1.003	0.993~1.014	0.514
Marital status
Unmarried	Ref			Ref
Married	1.371	1.013~1.856	0.041	NA	NA	0.361
Race
White	Ref
Black	0.797	0.566~1.123	0.194
Others	1.096	0.663~1.812	0.722
Tumor size	1.033	1.020~1.047	<0.001	1.002	1.000~1.004	0.026
Tumor side
Left	Ref
Right	1.142	0.870~1.499	0.340
Tumor grade
G1	Ref			Ref
G2	2.451	0.310~19.346	0.395	1.484	0.186~11.849	0.709
G3	11.387	1.584~81.864	0.016	4.462	0.608~32.727	0.141
G4	12.855	1.780~92.818	0.013	5.566	1.003~41.049	0.029
Gx	11.396	1.572~82.606	0.016	4.493	0.606~33.300	0.142
T stage
T1	Ref			Ref
T2	1.349	0.718~2.536	0.352	NA	NA	0.615
T3	2.560	1.830~3.582	<0.001	NA	NA	0.075
T4	3.764	2.280~6.214	<0.001	NA	NA	0.395
Tx	2.531	0.612~10.474	0.200	NA	NA	0.117
N stage
N0	Ref			Ref
N1	2.920	2.195~3.883	<0.001	1.638	1.182~2.271	0.003
Nx	2.777	1.210~6.373	0.016	1.989	0.748~5.290	0.168
M stage
M0	Ref			Ref
M1	4.977	3.721~6.657	<0.001	4.169	2.870~6.055	<0.001
Mx	4.912	1.545~15.613	0.007	1.551	0.396~6.074	0.529
Surgical type
Without	Ref			Ref
NSS	0.043	0.013~0.139	<0.001	0.160	0.047~0.547	0.004
RN	0.314	0.219~0.450	<0.001	0.553	0.357~0.858	0.008
Radiotherapy
Without	Ref			Ref
With	2.285	1.557~3.353	<0.001	NA	NA	0.561
Chemotherapy
Without	Ref			Ref
With	2.069	1.553~2.757	<0.001	0.497	0.343~0.720	<0.001