[Retracted] Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases

Table 1

Functional and KEGG pathway enrichment analysis of MAGE family and co-expressed genes. Top 3 terms were selected according to P-value.

(a) Biological processes

Term	Name	Count	P-value	Genes
GO:0007399	Nervous system development	9	2.22E-6	SEMA6A, EFNB3, DPYSL4, MDK, ZC4H2, PCDHB3, APBA2, PAFAH1B3, GPM6B
GO:0090103	Cochlea morphogenesis	4	3.90E-5	FZD2, PTK7, WNT5A, SOX9
GO:0002053	Positive regulation of mesenchymal cell proliferation	4	6.53E-5	WNT5A, LRP5, SOX9, FGFR2

(b) Molecular functions

Term	Name	Count	P-value	Genes
GO:1904929	Coreceptor activity involved in Wnt signaling pathway	2	1.83E-2	PTK7, GPC4
GO:0005515	Protein binding	36	1.85E-2	ISYNA1, MAGED1, ZC4H2, MAGEF1, LRP5, EFNA4, MAGEA9, TRO, CCND2, DPYSL4, SOX9, GPRASP1, MYH10, MAGEA3, TLE2, SEMA6A, FZD2, TLE1, CADM1, IGFBP2, WNT5A, LDOC1, SMARCA1, TBX3, PTK7, ADGRL1, ZNF415, MAGED2, BCOR, DZIP1, APBA2, ZNF334, PAFAH1B3, FGFR2, TSPYL5, ITM2C
GO:0005005	Transmembrane-ephrin receptor activity	2	2.74E-2	EFNB3, EFNA4

(c) Cellular components

Term	Name	Count	P-value	Genes
GO:0005887	Integral component of plasma membrane	11	2.19E-2	TRO, SEMA6A, EFNB3, CADM1, TUSC3, PTK7, PCDHB3, GPC4, EFNA4, FGFR2, EPHB3
GO:0045202	Synapse	7	2.53E-2	CADM1, ZC4H2, COL4A5, ADGRL1, APBA2, MYH10, FGFR2
GO:0031226	Intrinsic component of plasma membrane	11	2.82E-2	TRO, SEMA6A, EFNB3, CADM1, TUSC3, PTK7, PCDHB3, GPC4, EFNA4, FGFR2, EPHB3

(d) KEGG pathways

Term	Name	Count	P-value	Genes
hsa04310	Wnt signaling pathway	4	7.12E-4	FZD2, CCND2, WNT5A, LRP5, GPC4
hsa04360	Axon guidance	4	6.41E-3	SEMA6A, EFNB3, EFNA4, EPHB3
hsa04550	Signaling pathways regulating pluripotency of stem cells	4	8.39E-3	FZD2, WNT5A, FGFR2, TBX3