Upregulation of Versican Associated with Tumor Progression, Metastasis, and Poor Prognosis in Bladder Carcinoma

Table 2

Multivariate analysis of the correlation between clinicopathological parameters and survival time of patients with bladder cancer.

Parameters	Univariate analysis			Multivariate analysis
	HR	95% CI		HR	95% CI
Age	1.281	0.941-1.742	0.115	NA
Gender	1.385	0.920-2.086	0.119	NA
Tumor size	1.367	1.019-1.835	0.037	1.047	0.777-1.411	0.764
Tumor number	1.358	0.942-1.959	0.101	NA
Lymph node metastasis	1.694	1.209-2.373	0.002	0.967	0.669-1.398	0.859
Lymphovascular invasion	1.708	1.004-2.903	0.048	1.289	0.751-2.212	0.357
Distant metastasis	2.218	1.343-3.664	0.002	1.742	1.019-2.977	0.042
Depth of invasion	2.611	1.538-4.431	<0.001	1.787	1.038-3.076	0.036
Histological grade	1.352	0.982-1.860	0.064	NA
TNM stage	1.805	1.554-2.098	<0.001	1.867	1.578-2.210	<0.001
VCAN expression	1.611	1.172-2.214	0.003	1.820	1.292-2.565	0.001