Research Article
Ropivacaine-Loaded Poloxamer Binary Hydrogels for Prolonged Regional Anesthesia: Structural Aspects, Biocompatibility, and Pharmacological Evaluation
Table 2
Elastic (
) and viscous (
) moduli, viscosity (mPa·s) at 37°C and sol-gel transition temperatures (
, °C) for PL 407 and PL338 hydrogel formulations.
| | PL (%) | Formulations | (.105 mPa at ) | (.105 mPa at ) | (at ) | (.105 mPa·s at ) | (°C) |
| | 20 | PL407 | 246.1 | 135.2 | 1.82 | 1044 | 32.5 | | PL407-RVC | 295.3 | 78.4 | 3.76 | 2334 | 30.7 | | 25 | PL407 | 287.5 | 66.6 | 4.31 | 1658 | 24.5 | | PL407-RVC | 426.7 | 87.7 | 4.86 | 2473 | 24.1 | | 30 | PL407 | 1007 | 45.6 | 22.0 | 2218 | 21.4 | | PL407-RVC | 1116 | 65.0 | 17.2 | 2528 | 21.9 | | 20-10 | PL407/338 | 778.1 | 82.6 | 9.40 | 2204 | 23.8 | | PL407/338-RVC | 999.7 | 78.6 | 12.7 | 2587 | 23.8 | | 25-5 | PL407/338 | 876.5 | 63.6 | 13.8 | 2144 | 23.4 | | PL407/338-RVC | 638.4 | 48.9 | 13.0 | 2605 | 23.1 |
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