Ropivacaine-Loaded Poloxamer Binary Hydrogels for Prolonged Regional Anesthesia: Structural Aspects, Biocompatibility, and Pharmacological Evaluation

Table 3

RVC release constants (Krel) and mathematical model parameters for PL407 and PL407/338 hydrogels.

Formulations (PL, %)	Zero order		Higuchi		Korsmeyer-Peppas
	Krel (%.h^−1)		Krel (%.h^−1/2)		Krel (%.h^−n)
PL407 (20)	2.5	0.940	15.0	0.989	30.3	0.981	0.31
PL407 (25)	1.6	0.880	10.0	0.967	13.4	0.979	0.30
PL407 (30)	2.0	0.974	11.3	0.923	7.7	0.704	0.52
PL407/338 (20-10)	1.1	0.947	6.2	0.973	7.1	0.910	0.45
PL407/338 (25-5)	1.3	0.978	7.8	0.984	1.8	0.964	1.00