Ropivacaine-Loaded Poloxamer Binary Hydrogels for Prolonged Regional Anesthesia: Structural Aspects, Biocompatibility, and Pharmacological Evaluation

Table 4

Analgesia duration, area under the effect-time curve (AUEC) and histological scores after RVC-loaded PL-based hydrogels.

Groups	Formulations (PL, %)	Mean time analgesia duration (min.)	AUEC0-420 (min.)	Histological score median (minimum-maximum limits)
				2 days	7 days
Control (drug-free hydrogels)	PL407 (25)	—	—	2 (2–3)	2 (2–3)
	PL407 (30)	—	—	2 (1–3)	2 (1–3)
	PL407/338 (20/10)	—	—	2 (2–3)	2 (2–3)
	PL407/338 (25/5)	—	—	3 (2–3)	2 (2–3)
Test (RVC-loaded hydrogels)	Plain RVC			2 (2–3)	2 (2–3)
	PL407 (25)-RVC			2 (2–3)	2 (2–3)
	PL407 (30)-RVC			2 (1–3)	2 (1–3)
	PL407/338 (20/10)-RVC			2 (2–3)	2 (2–3)
	PL407/338 (25/5)-RVC			2 (1–3)	2 (1–3)

Data expressed as (/formulation) (ANOVA/Tukey-Kramer): , , . RVC vs PL407(25)-RVC; RVC vs PL407 (30)-RVC; RVC vs PL407/338 (25/5)-RVC; RVC vs PL407/338(20/10)-RVC; PL407 (25)-RVC vs PL407/338(25/5)-RVC; PL407(25)-RVC vs PL407/338(20/10); PL407(30)-RVC vs PL407/338(25/5)-RVC; PL407(30) vs PL407/338(20/10).