[Retracted] Protein Arginine Methyltransferase 5 Promotes the Migration of AML Cells by Regulating the Expression of Leukocyte Immunoglobulin-Like Receptor B4

Figure 8

The effect of inhibition of PRMT5 (EPZ015666) on the expression of related genes in AML cells. (a) After treatment of MV-4-11 and THP-1 cells with PRMT5 inhibitor (EPZ015666) for 24 h, the expression of PRMT5, p/T-mTOR, and LILRB4 in the CON group and EPZ015666 group was detected by Western blot. (c) J image grayscale analysis (a) showed that PRMT5 expression was downregulated in the EPZ015666 group. (d) J image grayscale analysis (a) showed that p-mTOR expression was downregulated in the EPZ015666 group. (e) J image grayscale analysis (a) showed that LILRB4 expression was downregulated in the EPZ015666 group. β-Actin was used as the internal control. The same experiments and similar results were reproduced on THP-1 cells, as shown in (b) and (f–h). Data are expressed by (; ).

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